A simple, reproducible and cost effective spectroscopic method developed and validated for ambrisentan in bulk and tablet dosage form. The drug was determined by using Acetonitrile as diluent at 260nm. Validation was performed as ICH guidelines for linearity, accuracy, precision, LOD and LOQ. The %recovery study for the proposed method was ranged between 99.21% and 99.67% indicating no interferences of the tablet excipients. Linearity was obtained in concentration range of 10-80�µg/ml for ambrisentan with correlation coefficient of 0.9996 and regression equation was found to be y=0.0124x.0019. The LOD and LOQ were found to be 0.48�µg/ml and 1.46�µg/ml respectively by simple UV spectroscopy.
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